The GPR4 antagonist NE-52-QQ57 increases survival, mitigates the hyperinflammatory response and reduces viral load in SARS-CoV-2-infected K18-hACE2 transgenic mice.

Front Pharmacol · 2025 · PMC12283652 · PMID 40703349

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showed a trendno p-value reported

IL-6, IL-10, IL-17A, and CXCL2 proteins showed a trend of reduced expression in the mouse lung in the GPR4 antagonist group ( Figure 2B ).

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a strong trendno p-value reported

Moreover, other inflammatory genes (e.g., Il-1β , Il-6 , Il-10 , Il-18 , Tnf-α , E-selectin , Atf3 , and Vcam1 ) also showed a strong trend of reduced expression, although not statistically significant ( Figure 2A ).

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