Reduction of inflammatory biomarkers underlies extracellular vesicle mediated functional recovery in an aged monkey model of cortical injury.

Front Aging Neurosci · 2025 · PMC12283759 · PMID 40703679

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hedged sentences

0.0860

closest p · 1.7× alpha

0.1000

boldest claim

The sentences

did not reach statistical significancep = 0.086so close (0.05 < p ≤ 0.1)

Similarly, the mean grasp pattern in the first week of post-operative testing (3 weeks post injury) in the current cohort revealed a similar trend to our previous cohort, with higher grasp rating in MSC-EVs compared to vehicle monkeys but did not reach statistical significance (Mann–Whitney Test, p = 0.086, Figure 1D ).

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approached significancep < 0.10so close (0.05 < p ≤ 0.1)

The following pro-inflammatory markers were downregulated significantly ( p < 0.05) or approached significance ( p < 0.10) ( Table 2 ) in MSC-EV vs.

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