The Impact of Age on the Effectiveness of Immune Checkpoint Inhibitors Therapy in Patients with Metastatic Non-Small-Cell Lung Cancer.

Geriatrics (Basel) · 2025 · PMC12286007 · PMID 40700281

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0630

boldest claim

The sentences

highly significantp < 0.0001actually significant

A strong and highly significant interaction was found between treatment duration and age (HR = 1.03, 95% CI: 1.02–1.04, p < 0.0001), indicating that the association between longer ICI treatment and higher risk of death is amplified in older patients.

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showed a trendp = 0.063so close (0.05 < p ≤ 0.1)

did not reach statistical significanceno p-value reported

While combination ICI with chemotherapy showed a trend toward increased risk (HR: 1.664; 95% CI: 0.974–2.848; p = 0.063), and ICI monotherapy showed a trend toward reduced risk (HR: 0.613; 95% CI: 0.352–1.062; p = 0.082), these findings did not reach statistical significance.

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