Upper-gastrointestinal tract metabolite profile regulates glycaemic and satiety responses to meals with contrasting structure: a pilot study.

Nat Metab · 2025 · PMC12286859 · PMID 40542296

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hedged sentences

0.0010

closest p · 0.0× alpha

0.0970

boldest claim

The sentences

highly significantP < 0.001actually significant

There was a highly significant main meal effect ( P < 0.001) on duodenal pellet carbohydrate composition, with duodenal pellets from Broken comprising a 30.54 ± 6.47 mg per 100 mg (46%) lower proportion of starch than Intact-S (adj.

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a negative trendP = 0.08so close (0.05 < p ≤ 0.1)

GIP exhibited a negative trend with desire to eat and composite appetite with borderline significance ( ρ = −0.33 and −0.35, P = 0.08 and 0.05; Extended Data Fig. 5b ), whereas no significant associations were observed between satiety levels and GLP-1 or PYY ( P > 0.05).

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borderline significanceP = 0.08so close (0.05 < p ≤ 0.1)

GIP exhibited a negative trend with desire to eat and composite appetite with borderline significance ( ρ = −0.33 and −0.35, P = 0.08 and 0.05; Extended Data Fig. 5b ), whereas no significant associations were observed between satiety levels and GLP-1 or PYY ( P > 0.05).

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showed a trendP = 0.097so close (0.05 < p ≤ 0.1)

Intact-S showed a trend toward increased serum methionine, although this was not statistically significant (FDR-adjusted P = 0.097).

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