A CARD9 deficiency mouse model recapitulates human chronic CNS candidiasis identifying defective monocytic cell responses in immunopathogenesis.

Surviving mice showed only a small trend toward higher fungal burden in treated mice verses the liposomal control treatment ( Supplemental Figure 9B ), likely reflecting the existing delay of monocyte recruitment observed by flow cytometry.

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The survival of Y91H KI mice was slightly longer than Card9 –/– mice but did not reach statistical significance.

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While WT B6N monocytes only showed a trend toward activation, Y91H KI mice showed a significant increase in CD11b and CD64 expression, suggesting an active monocyte response by day 4 p.i. in this background as well.

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