For fine wrinkle, compared with the placebo group, adapalene was associated with an odds ratio (OR) of 9.29 (95% CI [0.95, 90.92], P = 0.0554), indicating an effect that was close to significance but not statistically significant.
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Comparative efficacy of topical interventions for facial photoaging: a network meta-analysis.
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The sentences
In comparison, adapalene (OR = 9.29) exhibited a tendency towards significance under the fixed-effects model, indicating a potential effect.
In contrast, topical bakuchiol had an OR of 9.40 (95% CI [0.66, 134.36]), which did not reach statistical significance.