Quantitative Alterations in Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

Biomolecules · 2025 · PMC12292850 · PMID 40723889

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

Patients with CD had lower butyrate levels compared to controls, although the difference did not reach statistical significance (SMD = −1.44, 95% CI: [−2.92, 0.04], p = 0.06).

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showed a trendno p-value reported

Furthermore, patients with active IBD showed a trend toward lower propionate levels, suggesting that disease activity may further suppress SCFA production.

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