highly significantp < 0.001
The difference in IL-6 serum levels between patients and healthy controls was highly significant ( p < 0.001).
The difference in IL-6 serum levels between patients and healthy controls was highly significant ( p < 0.001).
[ 204 ] clearly demonstrated a statistically significant or near-significant reduction in IL-23, TNF-α, and IL-17F, along with a notable decrease in the ESR, CRP, PASI, and DLQI scores, supporting the clinical and immunological efficacy of biologic treatments in moderate-to-severe psoriasis.
In the same study conducted by Ozer Arican et al., the authors observed that serum IL-17 levels were slightly elevated in patients with psoriasis compared to healthy controls; however, this difference did not reach statistical significance.