Immunotoxicity Studies on the Insecticide 2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine (MPEP) in Hsd:Harlan Sprague Dawley SD<sup>®</sup> Rats.

If a significant trend was detected at p ≤ 0.01, Williams’ test was used [ 21 ]; if the trend was not significant Dunnett’s test was used [ 22 ].

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There was some evidence that MPEP impacted the immune system based upon a decreasing trend in pulmonary cell phagocytosis as well as modulation of the humoral immune response to the T-dependent antigen KLH.

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Most notable was a negative trend in pulmonary mononuclear cell phagocytosis with increases in dose of MPEP.

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There was also a positive trend in early humoral immune response (5 days after immunization) to keyhole limpet hemocyanin (KLH) as evidenced by increased serum anti-KLH IgM antibodies which was followed later (14 days following immunization) by decreasing trends in anti-KLH IgM and IgG antibody levels.

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