A CD4<sup>+</sup> T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction.

Mice that received Ptgir -deficient T cells showed a trend toward increased weight loss ( Figure 2A ), consistent with the observation that weight loss is a suitable readout for dextran sulfate sodium (DSS)-induced colitis but less so for T cell-transfer models. 23 The mice receiving Ptgir −/− naive CD4 + T cells, however, had a reduction in colon length, a dependable measure of more severe intestinal inflammation, when compared with animals that were injected with WT CD4 + T cells ( Figure 2B ).

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There was a trend (which did not reach statistical significance, probably because of the smaller number of animals we could inject due to limited materials) toward increased intestinal pathology in mice that received Ptgis -deficient T cells compared with those injected with WT T cells ( Figure 2G ).

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