Prednisolone add-on in early phase schizophrenia: A randomized, double-blind, placebo-controlled pilot study.

Brain Behav Immun Health · 2025 · PMC12302662 · PMID 40726776

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a clear trendno p-value reported

Outcomes In patients randomized to prednisolone (N = 6), a clear trend towards more pronounced reduction of psychotic symptoms was observed compared to the placebo group (N = 6).

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a nonsignificant trendno p-value reported

did not reach statistical significanceno p-value reported

The difference between the prednisolone- and placebo-treated groups did not reach statistical significance for the primary outcome (PANSS total score) after 6 weeks, but we observed a statistically significant difference in the PANSS general score and a nonsignificant trend for the PANSS total score at this point.

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