Association between cumulative TNF inhibitor dose and spinal radiographic progression in radiographic axial spondyloarthritis in patients with modified stoke ankylosing spondylitis spinal score ⩽24.

Ther Adv Musculoskelet Dis · 2025 · PMC12304511 · PMID 40734687

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.1300

boldest claim

The sentences

a negative trendp = 0.055so close (0.05 < p ≤ 0.1)

However, in a multivariable model adjusted for age and sex, a negative trend was observed in patients with a baseline mSASSS of ⩽24 at the 2-year interval (β = −0.888, 95% CI: −1.793 to 0.017, p = 0.055), although this association did not meet conventional thresholds for statistical significance.

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did not quite reach statistical significancep = 0.096so close (0.05 < p ≤ 0.1)

In multivariable model 2 (including log CRP), the cumulative TNFi dose exhibited a negative correlation with mSASSS changes but did not quite reach statistical significance ( p = 0.096).

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failed to reach statistical significancep = 0.130not close (p > 0.1)

In contrast, in Model 3 (including log-ESR), the correlation again failed to reach statistical significance ( p = 0.130).

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borderline significanceno p-value reported

It is important to note that the univariable models did not reveal a significant association, which, together with the borderline significance in the subgroup analysis, underscores the need for cautious interpretation.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.