Mapping Divergent Subfield-Specific Hippocampal Degeneration in Mild Cognitive Impairment Continuum: Volumetric, Cognitive, and Genetic Predictors of Accelerated Hippocampal Biological Aging.

CNS Neurosci Ther · 2025 · PMC12305119 · PMID 40726402

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hedged sentences

0.0010

closest p · 0.0× alpha

0.0770

boldest claim

The sentences

highly significantp < 0.001actually significant

This model was highly significant ( F (17, 31) = 5.450, p < 0.001, partial η 2 = 0.749), accounting for 74.9% of the variance (adjusted R 2 = 0.612).

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approached significancep = 0.054so close (0.05 < p ≤ 0.1)

None of the volumetric covariates individually reached significance ( p > 0.05), although the sex × APOE carrier interaction approached significance ( F (1, 31) = 4.023, p = 0.054, partial η 2 = 0.115).

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marginally significantp = 0.077so close (0.05 < p ≤ 0.1)

Parameter estimates suggested a marginally significant effect for the EMCI group relative to the LMCI group ( B = 9.510, SE = 5.204, t = 1.828, p = 0.077). 3.4.3.

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did not reach statistical significanceno p-value reported

In contrast, comparisons between the CN and EMCI groups generally did not reach statistical significance, suggesting that the volumetric reduction was most pronounced in the LMCI stage. 3.3.

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