Biomarkers and therapeutic targets in early Alzheimer's disease: an Olink proteomics study.

Although we reported nominally significant results ( p < 0.05) to maximize sensitivity for hypothesis generation, these results should be interpreted with caution until replicated in larger cohorts and MCC.

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First, compared with the healthy group, the levels of uPA and CDCP1 proteins both showed an increasing trend in AD patients and MCI patients.

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In our study, the uPA protein showed a trend of up-regulated expression in early AD compared to the healthy population, which corresponds to the protective mechanism one.

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