Pharmacogenomic insights into amlodipine response: the role of CACNA1D, CACNA1C, and TRIB3 variants in hypertensive patients.

PLoS One · 2025 · PMC12316260 · PMID 40748902

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hedged sentences

0.0560

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

near-significantp = 0.056so close (0.05 < p ≤ 0.1)

This mirrors its unadjusted OR of 7.37 (p < 0.001) and near-significant adjusted OR (2.84, p = 0.056), suggesting a potent synergistic effect between CACNA1D and CACNA1C , potentially due to their direct roles in calcium channel pharmacodynamics (Linde et al., 2012).

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approaching significanceno p-value reported

The adjusted OR was 2.550 (p = 0.093), suggesting a potential combined effect approaching significance.

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highly significantno p-value reported

The unadjusted OR for non-response was 7.367 (95% CI: 2.959–18.339, p < 0.001), demonstrating a highly significant association.

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