Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia.

A combined analysis revealed that the reduction in neurite complexity in patient organoids was highly significant with respect to number of branchpoints ( t -test, P = 0.013, Fig. 4b , upper left), neurite length ( t -test, P = 0.0209, Fig. 4b , upper middle) and number of primary neurites ( t -test, P = 0.0038, Fig. 4b , upper right).

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Quantification of various cell types revealed a nominally significant higher abundance of cycling radial glial (RG-div) and cycling intermediate progenitor cells (IPC-div) alongside a lower abundance of differentiated ENs in patient organoids compared to control organoids (Fig. 2c–e ).

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Specifically, proliferation assays of iPSC-derived NPCs obtained from controls and patients with 22q11.2 deletion syndrome diagnosed with a psychotic disorder showed a trend toward decreased proliferation 64 .

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