Clinical impact of first-line therapeutic strategies in BRAF V600E-mutant metastatic colorectal cancer: real-world evidence and prognostic insight.

These findings indicate a numerically longer OS in patients with right-sided BRAF V600E-mutant tumors, although the difference did not reach statistical significance.

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While the log-rank test yielded a p-value of 0.062—falling short of statistical significance—there was a clear trend toward inferior survival in the liver metastasis subgroup, suggesting that hepatic involvement may be a clinically meaningful prognostic factor in BRAF -mutant mCRC.

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