Plasma hepcidin level is elevated by water immersion-induced central fatigue via hepatic inflammatory response in male and female rats.

Although non‐heme iron concentration in the plantaris muscle of male rats in the central fatigue group tended to decrease, the changes did not reach statistical significance (Figure 6e ).

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In addition, IL‐1α, a proinflammatory cytokine that plays a crucial role in the initiation and propagation of inflammatory responses, showed a trend to increase after fatigue induction in male rats, regardless of the degree of fatigue.

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