Immune modulation following α and β<sup>-</sup> radionuclide therapy targeting fibroblast activation protein-α in a preclinical tumor model.

[ 225 Ac]Ac-DOTA-4AH29 treatment showed a trend toward increased B cells ( Figure 4b ), E7-specific CD8 + T-cells ( Figure 4i ) and cDC2 ( Figure 4n ), and decreased CD4 + T-cells ( Figure 4f ) and cDC1 ( Figure 4m ).

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On an individual gene expression level, elevated counts of IFN-induced protein with tetratricopeptide repeat 1 (Ifit1), Ifit3, IFN-induced protein 44 (Ifi44) and IFN regulatory factor 7 (Irf7) were observed following [ 131 I]I-GMIB-4AH29 and [ 225 Ac]Ac-DOTA-4AH29 treatment, although these changes did not reach statistical significance ( Figure 3d–g ).

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