Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease.

Notably, “Arginine biosynthesis” was similarly upregulated in both CR and DL-fed female 3xTg mice and approached significance in CR-fed male 3xTg mice (p = 0.066), the only pathway so similarly regulated in all four groups.

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CR-fed 3xTg mice had decreased energy expenditure relative to AL-fed mice in both sexes; however, while DL-fed males had lower energy expenditure, this effect did not reach statistical significance (Fig. 2 C, D, 2G, H).

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