Influence of capping chemotherapy prescriptions on efficacy and tolerability in medium and high-risk early-stage breast cancer.

Sci Rep · 2025 · PMC12322036 · PMID 40760003

Europe PMC DOI

hedged sentences

0.0710

closest p · 1.4× alpha

0.3000

boldest claim

The sentences

a slight trendp = 0.071so close (0.05 < p ≤ 0.1)

Regarding hematological toxicities, a slight trend was also observed in the occurrence of agranulocytosis ( p = 0.071).

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did not reach statistical significancep = 0.3not close (p > 0.1)

Regarding PFS, while the Kaplan-Meier method did not reach statistical significance ( p = 0.3; supplementary material), the univariate model identified a significant increase in progression risk for the [10–50[ capping group compared to the reference group (HR = 5.02, p = 0.035).

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showed a trendno p-value reported

Unexpectedly, the results showed a trend towards a lower risk of progression in the capped patient groups.

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