Gut microbiota links to histological damage in chronic HBV infection patients and aggravates fibrosis via fecal microbiota transplantation in mice.

Interestingly, patients with minimal liver injury (group M) were slightly older than those with significant liver injury, although this difference did not reach statistical significance ( P = 0.071).

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Beta diversity analysis, visualized through principal coordinate analysis (PCoA) based on UniFrac distances at the species level, revealed partial overlap between the groups but also a clear trend of separation, indicating shifts in the microbial community composition ( Fig. 2D ).

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