Efficacy and safety of dietary polyphenol supplements for COPD: a systematic review and meta-analysis.

Based on the pathological characteristics of the coagulation-fibrinolytic system imbalance in COPD patients, the comprehensive evidence-based evidence suggested that the modulatory effect of Salvia divinorum polyphenols intervention on D-D indexes was not only statistically highly significant (P<0.001), but also the magnitude of the effect (WMD=-0.43 μg/L) exceeded the criterion of the smallest clinically important difference in the field of thrombosis, suggesting that the intervention might modulate the activity of the fibrinolytic system bypathway to improve hypercoagulability in COPD patients, with clear clinical translational value. 3.6.4.

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It is worth noting that the overall meta-analysis of some indicators (such as FEV1/FVC) did not reach statistical significance, but subgroup analysis suggested the potential value of specific polyphenols.

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The weighted mean-variance calculation showed a combined effect size of 3.07% [95% CI: 0.32-4.09], with the lower boundary of the confidence interval exceeding the threshold of clinical equivalence (MCID=2%) and completely deviating from the null line (P=0.03).Forest plot analysis showed that the effect line was significantly right-skewed to the null region, the funnel plot symmetry test (Egger’s test, P=0.18) combined with Begg’s test (P=0.21) did not find any significant source of bias, and cumulative Meta-analysis showed that the effect sizes showed a trend of steady gain over time.

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