Barely Significant
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Impact of Medication Dose Optimization on Heart Failure Outcomes in African-American Female Patients: A Safety-Net Hospital Experience.

Cureus · 2025 · PMC12327919 · PMID 40772157

2
hedged sentences
0.0500
closest p · 1.0× alpha
0.0700
boldest claim

The sentences

did not reach statistical significancep<0.05actually significant
Interactions between RAS inhibitor and MRA (OR=0.72, 95% CI: 0.49-1.04, p=0.08) and between beta blocker and MRA (OR=1.47, 95% CI: 0.96-2.26, p=0.07) approached but did not reach statistical significance at the p<0.05 threshold (Figure 3 ).

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approached significancep=0.07so close (0.05 < p ≤ 0.1)
Interestingly, GDMT scores were not statistically significant predictors of one-year mortality after adjustment for confounding variables, although they approached significance in the unadjusted model (OR=0.86, 95% CI: 0.74-1.01, p=0.07).

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