Zagociguat prevented stressor-induced neuromuscular dysfunction, improved mitochondrial physiology, and increased exercise capacity in diverse mitochondrial respiratory chain disease zebrafish models.

Interestingly, s urf1 −/− and fbxl4 −/− zebrafish larvae had the most favorable effects seen at the level of mitochondrial biochemistry, where zag yielded a strong trend of increased complex I activities, ATP and NAD + levels, and significant reduction of the increased NADH/NAD + redox ratio in surf1 −/− and fbxl4 −/− low-dose azide-inhibited models.

also in 5,725 other papers

The NADH/NAD + ratio trended toward a decrease with zag treatment in surf1 −/− and fbxl4 −/− zebrafish (which is a change that is typically considered to be favorable in PMD), but zag treatment showed a trend toward further increasing the NADH/NAD + ratio in AB, AB + ROT, and, to a small degree, in ndufs2 −/− zebrafish ( Figure 3D(c) ).

also in 53,322 other papers