Mass cytometric detection of homologous recombination proficiency in circulating tumor cells to predict chemoresistance of metastatic breast cancer patients.

7 Vimentin and RAD51 expression also showed a trend to positively correlate, in line with the fact that RAD51 is coupled with EMT in breast and prostate cancer. 7 Vice versa, EMT has been reported to promote DDRs, triggering a vicious cycle of invasiveness and chemoresistance mechanisms. 7 Further evidence for different phenotypes of γH2AX + and 53BP1 + CTCs was provided by a negative correlation between 53BP1‐ and Vimentin‐positivities.

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RAD51 positivity significantly increased in MCF‐7/182R‐6 cells (four‐fold), while the less pronounced increase in MDA‐MB‐436 cells did not reach statistical significance.

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