Identification of candidate cardiomyopathy modifier genes through genome sequencing and RNA profiling.

The sodium-potassium ATPase subunit alpha 2 gene ( ATP1A2 ) was highly significant in the case-control comparison ( p < 4 × 10 −19 ).

also in 132,142 other papers

For FHOD3 , for example, expression was substantially lower in RCM mice, but showed a trend towards higher levels in the HCM validation cohort and in response to acute hypertrophy.

also in 53,322 other papers

We used a gene scoring algorithm that boosted nominally significant modifier phenotype associations with specialized annotation of hypertrophic cardiomyopathy and heart failure molecular phenotypes.

also in 7,732 other papers