Cox regression analysis has demonstrated that the three questionnaire times function as significant predictors of survival, except in the case of global health, which is close to being significant ( p = 0.054) ( Table 2 and Table S2 ). 3.3.
Factors which have failed to reach statistical significance in univariate analysis were sex ( p = 0.916) and the nodal status ( p = 0.696).
Another limitation of our analysis is that the third assessment time point did not reach statistical significance in the multivariate Cox regression.
The functional scores of physical functioning, role functioning, and global health, as well as the symptom scores of fatigue, dyspnoea, and chemotherapy side effects, were highly significant for overall survival at nearly all time points except for the immediate preoperative assessment.