Dark Sweet Cherry Anthocyanins Suppressed Triple-Negative Breast Cancer Pulmonary Metastasis and Downregulated Genes Associated with Metastasis and Therapy Resistance <i>In Vivo</i>.

Data from tumor gene expression was subjected to Spearman correlation analysis with p value (two tail) considered significant (*) for α ≤ 0.05, highly significant (**) for α ≤ 0.01, and very highly significant (***) for α ≤ 0.001 or (****) for α ≤ 0.0001, respectively.

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HIF gene expression was significantly downregulated only in the ACN group (0.24-fold compared to the control, p = 0.0029) and reduced in the DOX-ACN group (0.34-fold of the control), although the latter did not reach statistical significance due to high inter-animal variability ( Figure 2 C, left panel).

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The DOX-ACN treatment showed a trend toward enhanced efficacy involving CREB, PI3K, Akt-1, and Vim compared to DOX alone.

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