The Role of Landiolol in Coronary Artery Disease: Insights into Acute Coronary Syndromes, Stable Coronary Artery Disease and Computed Tomography Coronary Angiography.

J Clin Med · 2025 · PMC12347667 · PMID 40806838

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

did not reach statistical significancep = 0.07so close (0.05 < p ≤ 0.1)

Similarly, a sub-analysis of an observational study reported a lower rate of worsening heart failure at six months in the landiolol group, though the difference did not reach statistical significance (0% vs. 7%, p = 0.07) [ 15 ].

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a clear trendno p-value reported

A clear trend of HR reduction dose-dependency was established in a different observational study (higher doses achieving greater reductions), where an initial dose of 0.125 mg/kg was doubled and quadrupled ( p = 0.0008 and 0.0109, respectively) [ 22 ].

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