MDSC depletion during immunization with heat-killed <i>Mycobacterium tuberculosis</i> increases protection against BCG infection.

Depleting CCR2 + cells after M-MDSC induction but before the BCG infection (days 15, 16, 17) further reduced the bacterial loads in the lungs and spleen, although this did not reach statistical significance in the spleen ( Figure 5B ).

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Lungs and spleens even showed a trend towards higher bacterial loads than the controls.

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