Triglyceride-glucose index predicts cognitive decline and striatal dopamine deficiency in Parkinson disease in two cohorts.

NPJ Parkinsons Dis · 2025 · PMC12350777 · PMID 40804303

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

Furthermore, the correlation between the TyG index and αS-SAA parameters—TTT and T50%—did not reach statistical significance but showed a trend-level association(Additional file: Figure S3 ).

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a statistical trendno p-value reported

In the cross-sectional analysis, while we noted a distinct negative correlation between the TyG index and cognitive impairment in PD within the primary cohort, the PPMI cohort demonstrated merely a statistical trend without a statistically significant association.

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