The transmission blocking activity of artemisinin-combination, non-artemisinin, and 8-aminoquinoline antimalarial therapies: A pooled analysis of individual participant data.

PLoS Med · 2025 · PMC12352847 · PMID 40811722

Europe PMC DOI

hedged sentences

0.0543

closest p · 1.1× alpha

0.0789

boldest claim

The sentences

nearly statistically significantp = 0.0543so close (0.05 < p ≤ 0.1)

For example, the absolute difference between DHA-PPQ and AL in the relative reduction in molecular gametocyte density at day 14 is −19.35% (−39.05%, 0.36%), and the difference between these arms (19.35% lower reduction for DHA-PPQ) is nearly statistically significant ( p = 0.0543).

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near-significantp = 0.0789so close (0.05 < p ≤ 0.1)

Artemether-lumefantrine (AL) was significantly more potent at reducing mosquito infection rates within 48 h than dihydroartemisinin-piperaquine ( p = 0.0164) and sulfadoxine-pyrimethamine plus amodiaquine ( p = 0.0451), while this difference was near-significant for artesunate-amodiaquine ( p = 0.0789) and pyronaridine-artesunate ( p = 0.0519).

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