The Prognostic Value of the XPC rs2228001 Single Nucleotide Polymorphism in Cholangiocarcinoma.

Liver Int · 2025 · PMC12366541 · PMID 40833230

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0.0920

closest p · 1.8× alpha

0.0920

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did not reach statistical significancep = 0.092so close (0.05 < p ≤ 0.1)

In pCCA patients without adjuvant chemotherapy, the TT genotype also indicated a favourable trend for CSS and OS, but did not reach statistical significance (CSS: HR = 0.517, p = 0.092; OS: HR = 0.695, p = 0.218).

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showed a trendno p-value reported

In iCCA patients who did not receive adjuvant therapy, the TT genotype of XPC rs2228001 showed a trend towards improved RFS, CSS and OS compared to GG/GT genotypes, although statistical significance was not reached (RFS: HR = 0.676, p = 0.219; CSS: HR = 0.730, p = 0.328; OS: HR = 0.756, p = 0.332).

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