Whole exome sequencing identifies FANCM as a susceptibility gene for estrogen-receptor-negative breast cancer in Hispanic/Latina women.

Nat Commun · 2025 · PMC12370925 · PMID 40841357

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hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

We found a trend towards a greater effect size among women with high Indigenous American ancestry, but this did not reach statistical significance ( p = 0.06).

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nominally significantno p-value reported

We also show significant associations between known susceptibility genes, BRCA1 , BRCA2 , and PALB2 and overall BC risk, as well as nominally significant associations with CHEK2 , RAD51C , and TP53 .

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