Interaction of coexposure to inorganic arsenic and manganese: Tight junction injury of the blood-brain barrier and the relationship between oxidative stress and inflammatory cytokines in glial cells.

PLoS One · 2025 · PMC12377611 · PMID 40853884

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0.0100

closest p · 0.2× alpha

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a clear trendp < 0.01actually significant

The iAs and Mn coexposure group exhibited a clear trend of elevated IL-1β mRNA expression compared with the control group (p < 0.01, 0.001; see S3 Table, panel B and Fig 3B ).

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showed a trendp < 0.05actually significant

Furthermore, the expression of HO-1 protein in the iAs, Mn, and iAs+Mn groups showed a trend similar to that of Nrf2 protein expression (p < 0.05, 0.01, 0.001; see S4 Table , panel B and Fig 4C ).

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