Prognostic and Monitoring Utility of Serum CEA in Lung Adenocarcinoma: Differential Roles in EGFR-TKI and Chemotherapy Treatments.

Cancer Med · 2025 · PMC12378701 · PMID 40856433

Europe PMC DOI

hedged sentences

0.0620

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

did not reach statistical significancep = 0.062so close (0.05 < p ≤ 0.1)

Interestingly, Cox regression analysis incorporating an interaction term between elevated baseline CEA levels (≥ 5 ng/mL) and first‐line gefitinib treatment showed a trend toward improved survival in this subgroup, though it did not reach statistical significance (HR = 0.39; 95% CI: 0.15–1.05; p = 0.062).

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showed a trendp = 0.062so close (0.05 < p ≤ 0.1)

This interaction term showed a trend toward statistical significance (HR = 0.39; 95% CI: 0.15–1.05; p = 0.062) (Table S3 ), suggesting that elevated CEA levels may be associated with improved survival among patients treated with gefitinib.

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