Comparison of clinical outcomes between high-flow nasal cannula and non-invasive ventilation in acute exacerbation of COPD: a meta-analysis of randomized controlled trials.

BMC Pulm Med · 2025 · PMC12379362 · PMID 40859250

Europe PMC DOI

hedged sentences

0.0760

closest p · 1.5× alpha

0.0760

boldest claim

The sentences

did not reach statistical significanceP = 0.076so close (0.05 < p ≤ 0.1)

However, a non-significant trend emerged in treatment failure rates, with HFNC showing a higher failure rate (24.4%) compared to NIV (15.4%), although the difference did not reach statistical significance ( P = 0.076).

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showed a trendno p-value reported

Conclusion HFNC therapy showed a trend towards a higher treatment failure rate compared to NIV, though the difference was not statistically significant.

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