<i>ACTN3</i> genotype influences androgen response in developing murine skeletal muscle.

There is a highly significant differential Actn3 genotype effect on RCAN1-4 in response to DHT ( F 1,20 = 51.97, P < 0.0001).

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Our results also show a significant interaction between the effects of Actn3 genotype and ORX on p62 expression ( F 1,20 = 4.457, P = 0.0475); WT-ORX shows reduced p62 relative to WT-sham, consistent with up-regulated autophagy in WT following ORX, while p62 levels showed a trend for increase in KO-ORX relative to that in sham control ( Fig. 3H ).

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Testing for interaction effects between Actn3 genotype and DHT treatment for expression of complexes I to V did not reach statistical significance, but there was a significant interaction effect on the expression of porin ( F 1,19 = 26.93, P < 0.0001), with WT-DHT muscles showing reductions in porin, while KO-DHT muscles show increased expression relative to controls.

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