Immunorecovered but Exhausted: Persistent PD-1/PD-L1 Expression Despite Virologic Suppression and CD4 Recovery in PLWH.

Biomedicines · 2025 · PMC12383464 · PMID 40868140

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0690

boldest claim

The sentences

did not reach statistical significancep > 0.05actually significant

Although the models for LDL, TAG, total cholesterol, non-HDL cholesterol, and systolic blood pressure were well fitted, the effect of the clinical group did not reach statistical significance ( p > 0.05).

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near-significantp = 0.069so close (0.05 < p ≤ 0.1)

The percentage of Th_CD4+ cells expressing PD-L1 showed a near-significant increase (β = +2.29, p = 0.069), possibly indicating heightened immune activation, while B_CD19+ PD-1 expression showed a non-significant negative trend (β = −2.10, p = 0.097).

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