Exhausted and Senescent CD4<sup>+</sup> T Cells in Peripheral Blood and Their Impact as a Biological Marker for the Diagnosis of Benign and Malignant Ovarian Tumors.

Although the expression of the CD57 + marker and the senescence-associated phenotype (CD57 + CD28 − CD27 − ) did not reach statistical significance, we observed a trend toward increased frequencies of senescent CD4 + T cells.

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The percentage of frequency of CD57 + CD4 + T cells and CD57 + CD28 − CD27 − CD4 + T cells showed a trend toward being higher in the malignant group compared to the healthy donors and benign group, but the difference was not statistically significant ( p = 0.33 and p = 0.22, respectively).

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