Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome.

As expected, we also observed a decreasing trend of p21 protein levels.

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In contrast, p21 (CDKN1A), a key downstream target of p53, was significantly upregulated in control fibroblasts, although it did not reach statistical significance in HGPS cells ( Figure S1A,B ; corresponding full-scan blots, Figure S3 ).

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SIRT1 mRNA levels showed a trend toward downregulation in homozygous mice relative to wildtype, but the difference was not statistically significant ( Figure 7 B).

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