Primary Biliary Cholangitis: Immunopathogenesis and the Role of Bile Acid Metabolism in Disease Progression.

For instance, Seladelpar significantly reduced serum BAs [ 86 , 87 ], whereas Elafibranor significantly reduced circulating levels of the BA precursor 7α-hydroxy-4-cholesten-3-one (C4), showed a trend to reduce secondary BA levels with no apparent effect on primary BA levels [ 78 , 82 ].

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observed a significant reduction in all glyco- and tauro-conjugated BAs after two weeks of therapy in a cohort of PBC patients with pruritus treated with Linerixibat, although the decrease in total BA levels did not reach statistical significance.

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