The Roles of PD-L1, Ki-67, P53, and Cyclin D1 in PitNETs: Diagnostic and Prognostic Implications in a Series of 74 Patients.

Int J Mol Sci · 2025 · PMC12386402 · PMID 40869149

Europe PMC DOI

hedged sentences

0.1000

closest p · 2.0× alpha

0.2500

boldest claim

The sentences

a clear trendp = 0.10so close (0.05 < p ≤ 0.1)

Although a clear trend was observed, the difference did not reach statistical significance (exact Fisher’s test: p = 0.10).

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did not reach statistical significancep = 0.25not close (p > 0.1)

After adjusting for other biomarkers (P53, Ki-67, cyclin D1), the association remained elevated (adjusted OR = 2.35; 95% CI: 0.56–9.90), but this result still did not reach statistical significance ( p = 0.25).

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