Barely Significant
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Evaluation of Different Initial Doses of Envarsus in De Novo Kidney Transplant Recipients.

J Clin Med · 2025 · PMC12386444 · PMID 40869513

2
hedged sentences
0.1240
closest p · 2.5× alpha
0.1240
boldest claim

The sentences

did not reach statistical significancep = 0.124not close (p > 0.1)
Consistently with the pharmacokinetic pattern, tacrolimus doses were skipped because of high trough levels in 30.8% and 27.9% of patients in groups 1 and 2, respectively, compared with 14.3% and 14.0% in groups 3 and 4, although this overall difference did not reach statistical significance ( p = 0.124).

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near-significantno p-value reported
The same category showed near-significant differences for group 1 versus group 3 (p adj = 0.068) and group 2 versus group 4 (p adj = 0.055), while within-range exposure differed nominally between groups 1 and 3 (raw p = 0.018) but lost significance after correction (p adj = 0.107).

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