Pathway-Specific Genomic Alterations in Pancreatic Cancer Across Populations at Risk.

Int J Mol Sci · 2025 · PMC12386847 · PMID 40869017

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0671

boldest claim

The sentences

highly significantp = 1.02 × 10 −7actually significant

The median mutation count was lower in the H/L cohort compared to the NHW cohort, with a highly significant p -value ( p = 1.02 × 10 −7 ), suggesting potential differences in genomic instability between these populations.

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did not reach statistical significancep = 0.0671so close (0.05 < p ≤ 0.1)

Differences in MET mutation frequency did not reach statistical significance ( p = 0.0671).

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showed a trendno p-value reported

In contrast, the median fraction of the genome altered (FGA), a measure of chromosomal instability, showed a trend toward being higher in H/L patients, though not statistically significantly so.

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borderline significanceno p-value reported

While overall differences in other pathways were not statistically significant, several genes showed borderline significance, including ERBB4, ALK, HRAS, RIT1 (RTK/RAS), and CTNNB1 (WNT).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.