Sperm DNA Fragmentation Impairs Early Embryo Development but Is Not Predictive of Pregnancy Outcomes: Insights from 870 ICSI Cycles.

Int J Mol Sci · 2025 · PMC12386859 · PMID 40869243

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.1870

boldest claim

The sentences

a trend toward significancep = 0.057so close (0.05 < p ≤ 0.1)

In cycles with a lower proportion of top-quality blastocysts on day 5 (TQD5 < 50%, n = 751), the mean SDF was 16.41 ± 10.56, while in cycles with TQD5 ≥ 50% ( n = 119), it was slightly lower at 14.60 ± 9.05, showing a trend toward significance ( p = 0.057).

also in 3,729 other papers

did not reach statistical significancep = 0.187not close (p > 0.1)

27.8 ± 26.1%, p < 0.001), while the difference in top-quality embryo rate on day 3 did not reach statistical significance (16.7 ± 25.5% vs. 19.1 ± 23.4%, p = 0.187).

also in 111,027 other papers

borderline significantno p-value reported

Additionally, while the risk of miscarriage appeared higher with increasing SDF (OR = 0.961, p = 0.053), the result was borderline significant and should be interpreted with caution.

also in 11,409 other papers

showed a trendno p-value reported

Clinical pregnancy rates showed a trend toward reduction in the high SDF group (51.9% vs. 58.9%), although this difference was not statistically significant ( p = 0.113).

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.