Genetic Modulation of Silodosin Exposure and Efficacy: The Role of CYP3A4, CYP3A5, and UGT2B7 Polymorphisms in Benign Prostatic Hyperplasia Management.

J Pers Med · 2025 · PMC12387821 · PMID 40863448

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.1350

boldest claim

The sentences

showed a trendp = 0.053so close (0.05 < p ≤ 0.1)

ABCB1 1236C>T TT homozygotes (n = 25) showed a trend toward reduced RUV ( p = 0.053).

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did not reach statistical significancep = 0.135not close (p > 0.1)

However, for the rs4148738 C>T polymorphism, a trend toward greater IPSS improvement was noted in TT homozygotes (n = 16, ΔIPSS 1–4 = −9.16 ± 6.43) compared to CT heterozygotes (n = 59, ΔIPSS 1–4 = −4.62 ± 4.55) and CC homozygotes (n = 28, ΔIPSS 1–4 = −6.5 ± 5.28), though these differences did not reach statistical significance ( p = 0.135).

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