Conifer metabolite pisiferic acid restores activity in human Kv1.2 potassium channels carrying pathogenic sequence variants.

iScience · 2025 · PMC12392678 · PMID 40894870

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did not reach statistical significancep > 0.05actually significant

showed a trendno p-value reported

None of the other substitutions impaired pisiferic acid ability to hyperpolarize V 0.5act and E M ; R294A showed a trend toward the enhancement of pisiferic acid effects, but it did not reach statistical significance ( p > 0.05).

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