Barely Significant
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Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without.

Osteoarthr Cartil Open · 2025 · PMC12395530 · PMID 40893583

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non-KR cartilage thickness analysis, the discrimination between vKR case and control knees was greater when relying on medial rather than on lateral femorotibial cartilage loss, although differences in cartilage loss in the central lateral femorotibial compartment almost reached statistical significance.

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−278 ​± ​743 ​μm; OR 1.28 (95 ​% CI 0.80, 2.06), but the difference did not reach statistical significance (p ​= ​0.35; paired t -test).

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Other measures of cartilage loss and other observation intervals T -2 →T 0 cartilage loss in the central and total lateral compartments also appeared greater in vKR case than in vKR control knees, but the difference failed to reach statistical significance ( Table 2 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.